In this paper, we propose a multi-functional probe for recording biological activities in a living single neural cell. An active and simultaneous measurement method using a
glass micro injector as a multi-functional probe was examined. A measurement region was estimated to be
submicron order by using FDTD simulation. A prototype device was applied to a single neural cell in a buccal ganglion of Aplysia. Since active potentials and calcium concentration reactions induced by electric stimuli were recorded simultaneously, validity of our measurement method was confirmed.
Sumito Nagasawa, Isao Shimoyama, “Calcium Measurement Method by Fluorescent Analyses Using a Glass Micro Injector,” The 12th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '03), pp. 111-114, Boston, Massachusetts, USA, Jun. 8-12, 2003. [Proceedings]
Sumito Nagasawa, Isao Shimoyama, “Calcium Concentration Measurement by Local Fluorescent-Dye Injection,” Sensors and Actuators B, vol. 102, pp. 7-13, 2004. [Paper]
Sumito Nagasawa, Hidekazu Arai, Ryohei Kanzaki, Isao Shimoyama, “Integrated multi-Functional Probe for Active Measurements in a Single Neural Cell,” The 13th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '05), pp. 1230-1233, Seoul, Korea, Jun. 5-9, 2005. [Proceedings]